Antabuse (disulfiram) although your health care provider may decide to prescribe this medicine for a number of conditions, it is primarily intended for the treatment of chronic alcoholism in patients who were not successful battling the addiction with the help of other methods. This medicine must not be given to people that are already intoxicated (drunk) or if they do not understand the mechanism of this drug’s action. Antabuse is so powerful its effects can be felt even two weeks after the treatment was stopped. Drinking alcohol 12 hours before you take Antabuse and two weeks after the last dosage is not recommended.